2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137616A
    Sp-dUTPαS tetrasodium
    Sp-dUTPαS tetrasodium is an isomer of the sulfur-containing nucleotide dUTPαS.
    Sp-dUTPαS tetrasodium
  • HY-173169
    7-Methylguanosine 5′-monophosphate
    7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a building block of nucleic acid.
    7-Methylguanosine 5′-monophosphate
  • HY-43058
    5'-O-DMT-ibu-rG
    5'-O-DMT-ibu-rG is a useful model for a new class of DNA binding molecules for the development of potent and selective anti-cancer agents.
    5'-O-DMT-ibu-rG
  • HY-W570891
    DMTr-LNA-C(Bz)-3-CED-phosphoramidite
    DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    DMTr-LNA-C(Bz)-3-CED-phosphoramidite
  • HY-154242
    8-Methylguanosine
    8-Methylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Methylguanosine
  • HY-A0061R
    Trifluridine (Standard)
    Trifluridine (Standard) is the analytical standard of Trifluridine. This product is intended for research and analytical applications. Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors.
    Trifluridine (Standard)
  • HY-154604
    1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite
    1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite
  • HY-154059
    2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium
    2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium
  • HY-W011683S7
    2'-Deoxyadenosine monohydrate-15N5
    2'-Deoxyadenosine monohydrate-15N5 is the 15N labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-<sup>15</sup>N<sub>5</sub>
  • HY-134248A
    Tubercidin 5'-triphosphate tetrasodium
    Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) tetrasodium, a nucleoside analog, is an active metabolite of Tubercidin (HY-100126).
    Tubercidin 5'-triphosphate tetrasodium
  • HY-177059
    Nitrobenzylthioinosine 5'-monophosphate
    Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126).
    Nitrobenzylthioinosine 5'-monophosphate
  • HY-131816
    5'-dUMPS
    5'-dUMPS is a competitive inhibitor or regulator of enzymes that interacts with 2′-deoxypyrimidine-5′-monophosphate.
    5'-dUMPS
  • HY-152802
    2’-O-(3-Azidopropyl)-5-azacytidine
    2’-O-(3-Azidopropyl)-5-azacytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-O-(3-Azidopropyl)-5-azacytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2’-O-(3-Azidopropyl)-5-azacytidine
  • HY-154583
    3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
    3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
  • HY-171517
    2′-O-MOE-AMP
    2′-O-MOE-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-O-MOE-AMP
  • HY-W006395R
    1-Methylcytosine (Standard)
    		Chemical
    1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine.
    1-Methylcytosine (Standard)
  • HY-137695A
    ddGTPαS tetrasodium
    ddGTPαS tetrasodium, a nucleotide analog, can be used for chain extension in PCR assays.
    ddGTPαS tetrasodium
  • HY-123055R
    Adenosine dialdehyde (Standard)
    Adenosine dialdehyde (Standard) is the analytical standard of Adenosine dialdehyde. This product is intended for research and analytical applications. Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.
    Adenosine dialdehyde (Standard)
  • HY-W113972
    2'-F-iBu-G
    2'-F-iBu-G (2′-Deoxy-2′-fluoro-N-isobutyrylguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    2'-F-iBu-G
  • HY-111645R
    3-Methylcytidine (Standard)
    3-Methylcytidine (Standard) is the analytical standard of 3-Methylcytidine. This product is intended for research and analytical applications. 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
    3-Methylcytidine (Standard)